Table 2.

Effect of purified triterpene glycosides/aglycone from Cimicifuga species on cell proliferation in MDA-MB-453 (Her2 overexpressing) human breast cancer cells

Code	Plant Species	Chemical Name	M.W.	IC50 µg/ml	IC50 µM
A1	Cimicifuga acerina	Cimigenol 3-O-β-D-xylopyranoside	620	6	9.7
C2	Cimicifuga acerina	(22R)-22-hydroxycimigenol 3-O-β-D-xylopyranoside	636	29	45.6
d6	Cimicifuga dahurica	24-epi-7,8-didehydrocimigenol 3-O-β-D-xylpyranoside	618	7.2	11.7
d8	Cimicifuga dahurica	12 β-hydroxycimigenol 3-O-α-L-arabinopyranoside	636	55	86.5
d10	Cimicifuga dahurica	24-O-acetylisodahurinol 3-O-α-L-arabinopyranoside	684	17	24.9
d11	Cimicifuga dahurica	7,8-didehydrocimigenol 3-O-β-D-xylopyranoside	596	7.2	12.1
d13	Cimicifuga acerina	25-acetyl-7,8-didehydrocimigenol 3-O-β-D-xylopyranoside	638	3.2	5.0
dE	Cimicifuga dahurica	3-O-α-L-arabinopyranosyl cimigenol 15-O-β-D-glucopyranoside	804	72	89.6
Ac	Actaea racemosa	actein, β-D-xylopyranoside	676	5.7	8.4

MDA-MB-453 cells were treated with increasing concentrations of each of the Cimicifuga components for 96 h and the number of viable cells determined using a Coulter Counter. Similar results were obtained in an additional study.