Numbers of TFs controlling metabolic enzymes. (A) Histogram of numbers of TFs regulating all, catabolic, anabolic, and central energy enzymes. (*) Overrepresented groups; (§) underrepresented groups. (B) Box plots of numbers of general and specific TFs targeting different classes of enzymes. (C) Histogram of numbers of enzymes regulated by general TFs only, specific TFs only, and combinations of general and specific TFs.