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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: J Bioenerg Biomembr. 2008 Oct 1;40(5):541–549. doi: 10.1007/s10863-008-9182-6

Fig. 3.

Fig. 3

Is a color coded, diagrammatic representation of the electrostatically coupled movements of substrate electrons, substrate protons from the K-channel (H+(SK)), substrate protons from the D-channel (H+(SD)) and pumped protons (H+(P)), into, through and out of the oxidase. The figure is divided into three parts: The central panel is a cutaway diagram of the R.s. oxidase and shows the route taken by protons, during both phases of the catalytic cycle, and key amino acids, metal centers and water molecules. The panel on the left shows the counter charge movements of H+(P), in numbered sequence, that occur during the consumption of each of the four electrons in the overall metal/oxygen reduction phases. The panel on the right shows how discrete, electrostatic potentials are generated by the movement of substrate electrons and protons, in both the metal (MR) and oxygen (OR) reduction phases (first/second and third/fourth electrons respectively)