Table 1.
Parameter | Wild Type | Lmx1bf/f/p | |
---|---|---|---|
Age (days) | 263.6 ± 9.9 | 264.6 ± 17.5 | |
Weight (gm) | 33.0 ± 1.6 | 28.5 ± 1.1 | * |
TCore (°C) | 37.9 ± 0.2 | 36.4 ± 0.2 | ** |
V̇E (ml · min−1 gm−1) | 1.32 ± 0.06 | 1.04 ± 0.06 | ** |
fR (breaths · min−1) | 172.9 ± 6.9 | 143.6 ± 4.7 | ** |
VT (μl · breath−1 · gm−1) | 7.71 ± 0.37 | 7.24 ± 0.33 | |
TI(sec−1) | 0.1 ± 0.004 | 0.175 ± 0.007 | ** |
TE (sec−1) | 0.255 ± 0.012 | 0.255 ± 0.009 | |
VT/TI(ml · breath−1·sec−1) | 2.55 ± 0.14 | 1.20 ± 0.08 | ** |
V̇O2 (ml O2 min−1·gm−1) | 0.066 ± 0.003 | 0.056 ± 0.003 | * |
V̇E/V̇O2 | 20.8 ± 1.3 | 19.0 ± 0.7 |
All values are mean (± SEM); Age (at the time of study), core temperature (TCore), minute ventilation (V̇E), frequency (fR), tidal volume (VT), inspiratory time (TI), expiratory time (TE), ventilatory drive (VT/TI), oxygen consumption (V̇O2), convection requirement (V̇E/V̇O2). All measurements were obtained while breathing room air at an ambient temperature of 25°C. Comparisons were made with an unpaired t-test.
denotes P<0.05,
denotes P<0.005.