Figure 2.

A, STX (gray) significantly (FDR P < 0.05; FC > ±1.25) regulates a number of genes compared with vehicle in the arcuate. “Up” are up-regulated genes, and “Down” are down-regulated genes. B, The percent distribution of the STX-regulated genes from the arcuate total RNA samples analyzed by microarray and divided into eight functional categories: Translation & Transcription; Channels & and Membrane Proteins; Signaling Molecules; Cell Cycle & Growth; Metabolism and Mitochondria; Protein Trafficking & Catabolism; Cell Communication; and Unknown. The cDNA microarray chip was created from a brain-specific, estrogen-regulated guinea pig cDNA library produced using SSH.