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Serum estradiol levels (means ± se) in ovariectomized baboons after administration of estradiol (bolus iv injection at 1 μg/kg body weight and sc insertion of three SILASTIC brand capsules containing estradiol) at time 0 h (n = 10), VEGF Trap (bolus iv injection at 1 mg/kg body weight) at −24 h plus estradiol at 0 h (n = 4), or saline/hFc vehicle at 0 h (n = 8).
