Figure 8.

In vivo inhibition of KAP3 synthesis via icv administration of an AS ODN against KAP3 mRNA reduces glutamate release from the ME in vitro equally well in both OVX rats and OVX rats treated with EB. A and B, ME fragments were incubated as indicated in Materials and Methods, and medium samples were collected at 30-min intervals. Each point represents the mean ± sem of six independent observations. C, Total amount of glutamate released from the ME during a 3-h period. *, P < 0.05; **, P < 0.01 vs. SCR ODN (SCR)-treated groups.