Table 5. Stratification analysis for HLA-DRw53 and SUMO4 polymorphisms and the comparison of frequencies of SUMO4 allele and genotype in HLA-DRw53+ patients versus HLA-DRw53+ controls and HLA-DRw53- patients versus HLA-DRw53- controls.
| SNPs | Genotype allele | HLA-DRw53+ Patients n=203 (%) | HLA-DRw53+ Controls n=193 (%) | p value | pca value | HLA-DRw53- Patients n=28 (%) | HLA-DRw53- Controls n=109 (%) | p value | pca value |
|---|---|---|---|---|---|---|---|---|---|
| −847 G→A |
GG |
13 (6.5) |
20 (10.5) |
0.368 |
NSb |
3 (11.1) |
10 (9.4) |
0.200 |
NS |
| AG |
91 (45.7) |
83 (43.7) |
|
|
13 (48.1) |
33 (31.1) |
|||
| AA |
95 (47.7) |
87 (45.8) |
|
|
11 (40.7) |
63 (59.4) |
|||
| G |
117 (29.4) |
123 (32.4) |
0.370 |
NS |
19 (35.2) |
53 (25.0) |
0.133 |
NS |
|
| A |
281 (70.6) |
257 (67.6) |
|
|
35 (64.8) |
159 (75.0) |
|||
| −504 A→G |
AA |
43 (21.7) |
43 (22.6) |
0.742 |
NS |
11 (40.8) |
23 (21.5) |
0.114 |
NS |
| AG |
97 (49.0) |
98 (51.6) |
|
|
10 (37.0) |
48 (44.9) |
|||
| GG |
58 (29.3) |
49 (25.8) |
|
|
6 (22.2) |
36 (33.6) |
|||
| A |
183 (46.2) |
184 (48.4) |
0.538 |
NS |
32 (59.3) |
94 (43.9) |
0.044 |
NS |
|
| G |
213 (53.8) |
196 (51.6) |
|
|
22 (40.7) |
120 (56.1) |
|||
| +163 A→G |
AA |
96 (47.5) |
83 (43.0) |
0.590 |
NS |
11 (39.3) |
62 (56.9) |
0.216 |
NS |
| AG |
93 (46.0) |
94 (48.7) |
|
|
14 (50.0) |
36 (33.0) |
|||
| GG |
13 (6.4) |
16 (8.3) |
|
|
3 (10.7) |
11 (10.1) |
|||
| A |
285 (70.5) |
260 (67.4) |
0.333 |
NS |
36 (64.3) |
160 (73.4) |
0.178 |
NS |
|
| G |
119 (29.5) |
126 (32.6) |
|
|
20 (35.7) |
58 (26.6) |
|||
| +438 C→T | CC |
95 (47.3) |
82 (42.5) |
0.035 |
NS |
12 (42.9) |
53 (48.6) |
0.613 |
NS |
| CT |
95 (47.3) |
86 (44.6) |
|
|
12 (42.9) |
36 (33.0) |
|||
| TT |
11 (5.5) |
25 (13.0) |
|
|
4 (14.3) |
20 (18.3) |
|||
| C |
285 (70.9) |
250 (64.8) |
0.065 |
NS |
36 (64.3) |
142 (65.1) |
0.905 |
NS |
|
| T | 117 (29.1) | 136 (35.2) | 20 (35.7) | 76 (34.9) |
aBonferroni corrected p value; bNot significant.