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. 2009 Jan 1;20(1):21–32. doi: 10.1091/mbc.E08-04-0441

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© 2008 by The American Society for Cell Biology

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Figure 5. — vps-18(tm1125) mutation affects the biogenesis of endosomes and lysosomes. DIC and fluorescence images are shown for both N2 (a–d) and vps-18(tm1125) (e–h) coelomocytes in the following panels. (A and B) vps-18(tm1125) reduces the sizes of lysosomes and endosomes. Lysosomes are labeled by LMP-1::GFP (A) or mCherry:: CUP-5 (B) and indicated by arrows. Endosomes (early and late) are labeled by RME-8::RFP (A) or RME-8::GFP (B) and indicated by arrowheads. (C) vps-18(tm1125) affects the sizes of vesicles labeled by GFP::RAB-5 and RME-8::RFP. Vesicles that are only labeled by GFP::RAB-5 are indicated by arrows and vesicles that are only labeled by RME-8::RFP are indicated by arrowheads. (D) vps-18(tm1125) affects recycling endosomes. Recycling endosomes are labeled by RME-1::GFP and endosomes are labeled by RME-8::RFP. Arrows indicate RME-1::GFP in the peripheral membrane region and arrowheads indicate RME-8::RFP-positive vesicles. Bars, 5 μm.