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Evolution of mRNA quality control mechanisms. A schematic representation of a proposed scenario for the origin and divergence of components of trGTPase-associated mRNA decay mechanisms in archaea and eukaryotes is shown. Abbreviations indicate decay mechanisms known to function in eukaryotes and potentionally functional in archaea as follows: NSD – nonstop decay, NMD – nonsense-mediated decay, and NGD – no-go decay.
