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Expression levels of PXR target genes were evaluated to determine the effect of CA and hypothermia on drug metabolism and detoxification pathways. Real-time PCR analyses of liver RNA levels were determined from control, CA normothermia, and CA hypothermia groups. The hepatic expression of Oatp2, CYP3A2, CYP 2C2, and UGT1A1 are presented as average with standard division from 4-6 rats per treatment. (*p<0.05,**p<0.01,***p<0.001).
