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Co-transfection of hPXR and pGL3-rCYP3A2 natural promoter treated by human IL6 in HepG2 cells showed suppression of PXR activation. HepG2 cells were cotransfected with 1.4kb natural promoter pGL3-rCYP3A2-Luc reporter and human PXR. Transfected cells were treated with indicated IL6 concentration and/or rifampicin 10mM for 24 h before luciferase assay. Results are shown as —fold induction over vehicle control, which are represented as mean ± standard deviation from hexaplicate assay.
