Table 2.
Laboratory measures
| Parameter | Bacterial Dose | No Pump | IABC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Time after bacterial inoculation (mean (+/- SE)) | p-value* | Time after bacterial inoculation (mean (+/- SE)) | p-value+ | ||||||||||
| Baseline
|
24 h
|
48 h
|
72 h
|
96 h
|
Baseline
|
24 h
|
48 h
|
72 h
|
96 h
|
||||
| Animals alive | 19 | 16 | 14 | 13 | 11 | 14 | 11 | 8 | 7 | 6 | |||
| White blood cells (K/uL) | Low | 6.6(0.5) | 8.6(1.7) | 14.3(1.4) | 14.7(1.7) | 8.7(2.0) | 7.5(0.8) | 8.4(2.6) | 15.5(2.9) | 15.7(2.3) | 7.4(2.3) | ||
| High | 6.4(0.4) | 2.5(0.8) | 8.7(0.8) | 11.9(4.6) | 16.3(0.0) | 0.29 | 7.5(0.9) | 2.3(0.6) | 8.5(1.0) | 10.9(3.7) | 7.7(1.5) | 0.99 | |
| Hemoglobin (g/dL) | Low | 12.5(0.4) | 16.5(0.7) | 13.4(0.8) | 11.9(1.0) | 11.3(0.8) | 12.0(0.2) | 16.6(1.0) | 14.0(1.5) | 10.7(1.8) | 11.7(1.1) | ||
| High | 11.4(0.4) | 18.2(0.6) | 14.0(0.5) | 12.8(1.1) | 11.2(0) | 0.18 | 13.7(0.8) | 19.6(1.5) | 15.1(1.4) | 14.6(0.8) | 12.0(1.2) | 0.18 | |
| Platelets (K/uL) | Low | 221(14) | 189(14) | 105(9) | 86(13) | 80(14) | 190(15) | 149(13) | 52.4(5.0) | 21.3(4.5) | 36.3(4.3) | ||
| High | 187(17) | 170(17) | 102(27) | 63(71) | 137(0) | 0.55 | 247(19) | 129(20) | 47(4) | 28.3(17.7) | 45(13) | 0.04 | |
| Bicarbonate (mmol/L) | Low | 17.1(0.4) | 11.1(0.5) | 11.8(0.3) | 13.2(0.7) | 14.3(1.0) | 15.5(0.3) | 11.1(0.8) | 11.9(0.7) | 12.3(0.6) | 12.8(0.5) | ||
| High | 16.8(1.5) | 12.6(1.0) | 13.0(1.1) | 13.3(1.1) | 15.1(0) | 0.48 | 13.2(1.2) | 9.6(1.2) | 11.2(1.2) | 11.3(1.2) | 13.1(1.1) | 0.81 | |
| Sodium (mmol/L) | Low | 145 (1) | 144(1) | 142(1) | 142(1) | 144(1) | 143 (1) | 143(2) | 141(2) | 142(3) | 144(4) | ||
| High | 144(1) | 139(2) | 139(4) | 141(8) | 145(0) | 0.006 | 145(1) | 142(2) | 138(2) | 136(2) | 136(6) | 0.62 | |
| Chloride (mmol/L) | Low | 117(1) | 126(1) | 124(1) | 123(1) | 124(1) | 117(1) | 125(1) | 124(2) | 123(3) | 125(4) | ||
| High | 115(1) | 119(2) | 122(4) | 122(4) | 121(0) | 0.01 | 118(1) | 122(2) | 122(3) | 121(3) | 118(1) | 0.91 | |
| Potassium (mmol/L) | Low | 3.7(0.1) | 3.6(0.1) | 3.4(0.1) | 3.2(0.2) | 3.2(0.2) | 3.5(0.1) | 3.3(0.2) | 3.5(0.1) | 3.4(0.1) | 3.4(0.3) | ||
| High | 3.8(0.1) | 4.3(0.3) | 4.0(0.4) | 4.5(1.3) | 4.2(0) | 0.01 | 3.8(0.1) | 4.7(0.4) | 3.9(0.2) | 4.2(1.0) | 4.3(0) | 0.41 | |
*
, low vs. high bacterial dose;
+
, Interaction IABC vs. no pump comparing low vs. high bacterial dose