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Proposed model for redox-dependent binding and release of Yap4 from the Lot6–20S proteasome complex. Under conditions in which the Lot6 flavin is reduced and does not get reoxidized by quinone species, Yap4 is bound to the Lot6–proteasome complex and thus is retained in the cytosol. In the presence of quinones, Yap4 is released from the complex and relocalizes to the nucleus to induce the transcription of target genes.
