Table 2.
Comparison of mRNA expression in the left ventricle of trained (TRN) and sedentary rats (SED) for putative hypertrophc triggers and pathological hypertrophy and inflammatory markers
| Target | Sedentary | Trained | P value |
|---|---|---|---|
| Hypertrophic triggers | |||
| Angiotensin II receptor 1A | |||
| Agtr1a-Rn00578456_m1 | 1.09 ± 0.06 | 1.14 ± 0.08 | n.s. 0.701 |
| Endothelin-1 | |||
| Edn1-Rn00561129_m1 | 1.05 ± 0.09 | 0.89 ± 0.10 | n.s. 0.245 |
| Endothelin-1 receptor type A | |||
| Ednra-Rn00561137_m1 | 0.97 ± 0.04 | 1.00 ± 0.03 | n.s. 0.518 |
| Endothelin-1 receptor type B | |||
| Ednrb-Rn00569139_m1 | 1.18 ± 0.08 | 1.46 ± 0.08 | TRN > SED 0.027 |
| Insulin-like growth factor 1 | |||
| Igf1-Rn00710306_m1 | 1.25 ± 0.06 | 1.18 ± 0.09 | n.s. 0.559 |
| Insulin-like growth factor 1 receptor | |||
| Igf1r-Rn00583837_m1 | 1.09 ± 0.03 | 1.16 ± 0.07 | n.s. 0.381 |
| Insulin-like growth factor 1 binding protein | |||
| Igfbp3-Rn00561416_m1 | 1.33 ± 0.07 | 1.25 ± 0.08 | n.s. 0.441 |
| Pathological hypertrophy and inflammatory markers | |||
| β-Myosin heavy chain | |||
| Myh7-Rn00568328_m1 | 1.26 ± 0.07 | 1.11 ± 0.18 | n.s. 0.554 |
| Atrial natriuretic peptide | |||
| Nppa-Rn00561661_m1 | 0.87 ± 0.20 | 1.19 ± 0.33 | n.s. 0.405 |
| Brain natriuretic peptide | |||
| Nppb-Rn00580641_m1 | 1.55 ± 0.17 | 1.26 ± 0.15 | n.s. 0.211 |
| Tumour necrosis factor α | |||
| Tnf-Rn00562055_m1 | 1.39 ± 0.09 | 0.90 ± 0.13 | SED > TRN 0.007 |
Assay identification reference is given below target's common name. Data are from n= 10 hearts from trained and 10 from sedentary rats. P values are the probability derived from Student's unpaired t test; n.s. not significant.