Table 3.

Distribution of evolutionary relevant mutations among phenotypic classes and among regulatory network levels.

	Morphology	Physiology	Behavior	DGB member1	Non-DGB member2
Coding3	62	170	2	132	102
Cis-regulatory	43	29	2	34	37
Other4	3	20	0	9	14
Total	108	219	4	175	153
Null5	41	58	0	22	77

¹Gene is a known or presumptive member of a differentiation gene battery (DGB).

²Gene known or presumed to reside upstream of a DGB. Three genes could not be assigned to the DGB or non-DGB category because their function is unknown.

³Includes mutations altering mRNA splicing.

⁴Includes gene duplications, gene losses, stable DNA methylation, and four cases in which the mutations were mapped to a gene but not localized to a coding versus cis-regulatory change.

⁵Alleles presumed null based on existence of premature stop codons, altered splice sites, and deletions of part or all of the protein-coding sequence.