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. 2008 Jul;25(7):818–825. doi: 10.1111/j.1464-5491.2008.02490.x

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© 2008 The Authors. Journal compilation © 2008 Diabetes UK.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Logistic regression analysis analysing the efficacy of epalrestat vs. control. Efficacy analysis was based on a defined index, in which patients satisfying at least one of the following requirements during a 3-year period were classified as responders to treatment and odds ratios (ORs) were calculated: 1, ≥ 1 m/s increase in median motor nerve conduction velocity (MNCV); 2, ≥ 5% decrease in F-wave latency; 3, ≥ 50% increase of time in vibration perception threshold (VPT); 4, ≥ 50% decrease in the mean score of 10 symptoms.