Reduction of cytochrome C by TA0289 in the presence of NorW and NADH. A 200 mg ml−1 sample of cytochrome C in 50 mM Hepes-Na (pH 7.5), 0.2 M NaCl, and 10% glycerol in the presence of 1 µM NorW and 1.9 µM TA0289 was scanned (trace a). Reduction of cytochrome C was achieved by the anaerobic addition of 200 µM NADH. The fully reduced spectrum is trace b. INSET: An absorbance trace at 550 nm following the time course for the reduction of 200 µg ml−1 cytochrome C in the presence of 200 µM NADH, 1 µM NorW, and 1.9 µM TA0289 in the same buffer, obtained from a single wavelength stopped flow experiment.