Skip to main content
. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Nat Rev Cancer. 2008 Oct 16;8(11):880–887. doi: 10.1038/nrc2505

Figure 3. Signalling pathways downstream of vascular endothelial growth factor (VEGF-A)xxx and VEGF-Axxxb.

Figure 3

a | The VEGF-Axxx-mediated angiogenic response acts primarily through VEGF receptor 2 (VEGFR2) to initiate multiple downstream pathways15,16. b | VEGF-A165b results in transient, weak phosphorylation and the downstream signalling (denoted ‘?’) from such qualitatively different phosphorylation is largely unknown (see REF. 25 for details). Erk, extracellular signal-regulated kinase; HSP27, heat shock protein 27; NOS3, endothelial nitric oxide synthase; PI3K, phosphoinositide 3-kinase; PKC, protein kinase C; RAC, Ras-related C3 botulinum toxin substrate; PLCγ, phospholipase Cγ; SHB, SH2 domain-containing adaptor protein B; SHC1, SH2 domain-containing transforming protein 1; VRAP, VEGF receptor-associated protein.