. 2008 Nov 6;7:83. doi: 10.1186/1476-4598-7-83

Table 2.

Correlation analysis of SFRP2 promoter methylation with clinicopathological and immunohistochemical patient characteristics

	SFRP2 promoter

Variable	n^a	Unmethylated (%)	Methylated (%)	R^b	P^c
Total	199	34 (17)	165 (83)

*Clinicopathological factors*

Age at diagnosis
< 60 years	114	24 (21)	90 (79)	0.122	0.091
≥ 60 years	85	10 (12)	75 (88)

Tumor size^d
pT1	70	11 (16)	59 (84)	-0.013	1.000
pT2 – 4	114	19 (17)	95 (83)

Lymph node status^d
pN0	89	19 (21)	70 (79)	0.129	0.106
pN1 – 3	85	10 (12)	75 (88)

Histological grade
G1 – G2	109	13 (12)	96 (88)	-0.139	0.069
G3	76	17 (22)	59 (78)

Histological type
ductal	155	26 (17)	129 (83)	-0.057	0.434
lobular	24	1 (4)	23 (96)
other	14	5 (36)	9 (64)

*Immunohistochemistry*

Estrogen receptor
negative (IRS^e0 – 2)	64	13 (20)	51 (80)	0.084	0.295
positive (IRS 3 – 12)	123	17 (14)	106 (86)

Progesterone receptor
negative (IRS^e0 – 2)	70	14 (20)	56 (80)	0.083	0.304
positive (IRS 3 – 12)	117	16 (14)	101 (86)

^aOnly female patients with primary, unilateral, invasive breast cancer were included. ^bPearson's correlation coefficient. ^cFisher's exact test (two-sided). ^dAccording to UICC: TNM Classification of Malignant Tumours [38]. ^eIRS = immunoreactivity score [40]. Significant P-values marked in bold face.