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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neurobiol Aging. 2007 Jun 6;29(12):1795–1804. doi: 10.1016/j.neurobiolaging.2007.04.023

Figure 3. The effect of physostigmine on NMDAR-EPSC is through a mechanism depending on Ca2+.

Figure 3

A. Plot of NMDAR-EPSC as a function of time and physostigmine (40 µM) application in a neuron loaded with BAPTA (10 mM). Inset, representative current traces (at time points denoted by #). Scale bars: 20pA/100ms. B, C. Plot of NMDAR-EPSC as a function of time and drug application. Note that thapsigargin (10 µM, B), but not KN93 (10 µM, C), prevented the effect of physostigmine. Inset (B, C), representative current traces (at time points denoted by #). Scale bars: 10pA/100ms. D. Bar plot summary showing the percentage reduction of NMDAR-EPSC by physostigmine in neurons treated with different agents. *: p < 0.005, t-test.