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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Neurobiol Aging. 2007 Jun 6;29(12):1795–1804. doi: 10.1016/j.neurobiolaging.2007.04.023

Figure 5. The regulation of NMDAR-EPSC by physostigmine is impaired in APP transgenic mice.

Figure 5

A. Plot of normalized NMDAR-EPSC as a function of time and physostigmine (40 µM) application in cortical pyramidal neurons from a 2-month-old wild type mouse (WT) and a 2-month-old APP transgenic mouse (APP). B. Representative current traces taken from records used to construct A (at time points denoted by #). Scale bars: 20pA/100ms. C. Bar plot summary of the percentage reduction of NMDAR-EPSC by physostigmine in wild-type and APP transgenic mice at different ages (6 weeks, 2 months, and 16 months). *: p < 0.001; **: p < 0.005, t-test. D. Dose response curves showing the effect of physostigmine on NMDAR-EPSC in 4-month-old WT and APP transgenic mice. ‡: p < 0.01; **: p < 0.005, t-test.