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. 2008 Dec 1;119(1):193–202. doi: 10.1172/JCI36983

Figure 5. IRBIT activates CFTR.

Figure 5

(A) The Cl– current in HEK cells transfected with CFTR (open circles) or CFTR and IRBIT (filled circles) in a 1:3 ratio is shown. Where indicated, the cells were stimulated with forskolin and treated with CFTRinh-172. (B) Summary of current density in cells expressing CFTR (green) or CFTR and IRBIT in 1:1 (blue) or 1:3 (red) ratios are shown. Results are given as the mean ± SEM of the number of experiments indicated in the columns. (C) The surface expression of CFTR in cells transfected with vector (control), CFTR, or CFTR and IRBIT in a 1:3 ratio, as indicated, is shown. (D) Example traces of single CFTR channel activity are shown (c, close channel state; o, open channel state), and (E–G) show the (mean ± SEM) of (E) the open probability (NPo), (F) burst duration, and (G) interburst duration.