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. 2008 Dec 15;119(1):61–69. doi: 10.1172/JCI35997

Figure 6. Loss of IL-17F and inhibition of IL-17A does not significantly impact on the development of EAE.

Figure 6

EAE was induced in IL-17F–deficient mice by immunization with MOG35–55/CFA. To antagonize IL-17A function, 200 μg of neutralizing anti–IL-17A mAb or the respective isotype control mAb was injected i.p. every fourth day, starting on day 4 after immunization. The graph shows the development of EAE according to clinical scores in 1 out of 2 independent experiments. Error bars represent mean ± SEM. Iso. ctrl., isotype control.