Figure 1.

Mast cells isolated from the ruby-eye mutant mouse show a large increase in the number of transient fusion events. Step changes in cell membrane capacitance that occur during the degranulation of mast cells isolated from wild-type mice (A) and ruby-eye mice (B). The traces are from a continuous record (total of 2.7 min in A and 3.2 min in B) during the initial phase of the degranulation. The transient fusion events in A are indicated by (∗). The degranulation was triggered by adding 3 μM GTPγS to the patch-pipette solution.