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. 2009 Jan 16;5(1):e1000269. doi: 10.1371/journal.ppat.1000269

Figure 7. Common regulation of cell-death– and cytokine-related genes HCV-infected cultured hepatocytes and patient liver tissue.

Figure 7

(A) Expression of cell-death–related genes in individual liver biopsies from HCV-infected liver transplant patients (n = 25). Two-dimensional hierarchical clustering was done using Resolver System software with an agglomerative algorithm, complete link heuristic criteria, and Euclidean correlation metric. Each column represents gene expression data from an individual experiment comparing a single HCV-infected liver tissue to a pool of normal, uninfected liver tissue. Heatmap depicts a subset of 96 genes from Figure S1 that are regulated (2-fold, p value<0.05) in at least 3 experiments. Patients with fibrosis are indicated in red text while non-fibrotic patients are shown in black text. (B) Expression of cytokine- related genes in liver biopsy tissue from HCV-infected liver transplant patients. Heatmap depicts a subset of 50 genes from Figure 5 that are regulated (2-fold, p value<0.05) in at least 3 experiments. Patients with fibrosis are indicated in red text while non-fibrotic patients are shown in black text.