Table 3. Evaluation of the Association of Serum Lipid and Cholesterol Levels with Local Ancestry at 19 Lipid Loci Identified or Validated in Recent GWAS.
Trait | Gene | p-value |
LDL | APOB | 0.0031 |
APOE | 0.812 | |
HMGCR | 0.858 | |
LDLR | 0.843 | |
MVK | 0.826 | |
NCAN | 0.687 | |
PCSK9 | 0.365 | |
SORT1 | 0.475 | |
TRIB1 | 0.224 | |
HDL | ABCA1 | 0.71 |
APOA5 | 0.37 | |
CETP | 0.65 | |
GALNT2 | 0.47 | |
LIPC | 0.23 | |
LIPG | 0.11 | |
LPL | 0.012 | |
MLXIPL | 0.75 | |
TRIB1 | 0.61 | |
TG | ANGPTL3 | 0.81 |
APOA5 | 0.86 | |
APOB | 0.07 | |
GALNT2 | 0.37 | |
GCKR | 0.013 | |
LPL | 0.14 | |
MLXIPL | 0.19 | |
NCAN | 0.86 | |
TRIB1 | 0.83 |
Local ancestry values were estimated using ANCESTRYMAP and the strength of the association of local ancestry with each trait was evaluated by linear regression as in Table 2. Associations significant at the p<0.05 level are shown in bold.