Table 2. Amino acids in each pocket being critical for peptide-HLA groove interaction according to their electrostatic behavior.

Effect		P1	P4	P7	P9
Anchoring	Primary	α55E	α24F	-	-
		β81H
	Secondary		α9Q		α71E
		α43W	β13R *	β28D	α76R
		β83Y	β26F	β61W	β9W
			β78Y
Recognition	Fine	-	β13R	β28D	-
			β26F
	Coarse	α24F	α9Q		α72I
		α32F	β74A	β47F	α76R
		α43W	β78Y	β61W	β57D
		β85V

^*Polymorphic positions are shown in bold-types.