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. 2009 Jan 12;4(1):e4176. doi: 10.1371/journal.pone.0004176

Table 1. Interferon gene expression changes following NTHi lysate treatment.

Symbol Definition 2 h fold change 4 h fold change Accession
G1p2 Interferon alpha-inducible protein 4.51 8.00 NM_015783.1
Icsbp1 Interferon consensus sequence binding protein 1 1.20 1.07 NM_008320.2
Ifi1 Interferon inducible protein 1 3.68 2.38 NM_008326.1
Ifi16 Interferon gamma-inducible protein 16 1.22 2.24 NM_008329.1
Ifi202b Interferon activated gene 202B 2.48 ND NM_008327.1
Ifi203 Interferon activated gene 203 1.44 2.40 NM_008328.1
Ifi205 Interferon activated gene 205 24.22 53.00 NM_172648.2
Ifi30 Interferon gamma inducible protein 30 1.044 0.72 NM_023065.2
Ifi35 Interferon-induced protein 35 1.20 1.34 NM_027320.1
Ifi47 Interferon gamma inducible protein 4.66 3.60 NM_008330.1
Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 ND ND NM_008331
Ifit2 Interferon-induced protein with tetratricopeptide repeats 2 2.01 4.23 NM_008332.2
Ifit3 Interferon-induced protein with tetratricopeptide repeats 3 3.08 4.21 NM_010501.1
Ifitm1 Interferon-induced transmembrane protein 1 2.66 2.59 NM_026820.2
Ifitm2 Interferon-induced transmembrane protein 2 1.75 1.36 NM_030694
Ifitm3 Interferon-induced transmembrane protein 3 1.70 1.34 NM_025378.1
Ifitm5 Interferon-induced induced transmembrane protein 5 1.53 2.40 NM_053088
Ifitm7 Interferon-induced transmembrane protein 7 0.70 0.72 NM_028968
Ifna1 Interferon alpha family gene 1 1.74 1.69 NM_010502.1
Ifna2 Interferon alpha family gene 2 ND ND NM_010503.1
Ifna4 Interferon alpha family gene 4 ND ND NM_010504.1
Ifna5 Interferon alpha family gene 5 0.93 0.81 NM_010505
Ifna6 Interferon alpha family gene 6 ND 9.08 NM_008335.1
Ifna7 Interferon alpha family gene 7 1.50 0.55 NM_008334
Ifna9 Interferon alpha family gene 9 ND ND NM_010507.1
Ifna11 Interferon alpha family gene 11 1.05 0.94 NM_008333
Ifna12 Interferon alpha family gene 12 ND ND NM_177361.2
Ifna13 Interferon alpha family gene 13 ND ND NM_177347.2
Ifnar1 Interferon (alpha and beta) receptor 1 1.87 4.84 NM_010508.1
Ifnar2 Interferon (alpha and beta) receptor 2 2.63 1.87 NM_010509.1
Ifng Interferon gamma ND 8.63 NM_008337.1
Ifngr1 Interferon gamma receptor 1 1.03 0.69 NM_010511.1
Ifngr2 Interferon gamma receptor 2 4.67 2.96 NM_008338.2
Ifrd1 Interferon-related developmental regulator 1 7.09 11.35 NM_013562
Ifrd2 Interferon-related developmental regulator 2 0.85 1.05 NM_025903.1
Ifrg15 Interferon alpha responsive gene 1.158 1.34 NM_022329.2
Igtp Interferon gamma induced GTPase 1.92 2.57 NM_018738.2
Irebf1 Interferon response element binding factor 1 ND 9.45 NM_013714.1
Irf1 Interferon regulatory factor 1 5.43 1.96 NM_008390.1
Irf2 Interferon regulatory factor 2 1.01 0.93 NM_008391.2
Irf2bp1 Interferon regulatory factor 2 binding protein 1 0.68 0.82 NM_178757.3
Irf3 Interferon regulatory factor 3 1.24 0.93 NM_016849.2
Irf4 Interferon regulatory factor 4 2.63 1.73 NM_013674.1
Irf5 Interferon regulatory factor 5 1.81 1.57 NM_012057.1
Irf6 Interferon regulatory factor 6 1.11 1.02 NM_016851.1
Irf7 Interferon regulatory factor 7 1.60 3.18 NM_016850.1
Isg20 Interferon-stimulated protein 1.90 1.69 NM_020583.4
Isgf3g Interferon dependent positive acting transcription factor 3 gamma. 2.27 1.24 NM_008394.2
Jak1 Janus kinase 1 1.30 1.25 NM_146145.1
Jak2 Janus kinase 2 2.26 1.44 NM_008413.1
Mx1 Myxovirus (influenza virus) resistance 1 8.02 16.69 NM_010846
Oas1g 2–5 oligoadenylate synthetase 1G 2.47 3.00 NM_011852.2
Prkr Protein kinase interferon-inducible double stranded RNA dependent 1.69 2.63 NM_011163.2
Prkrir Protein kinase interferon-inducible double stranded RNA dependent inhibitor repressor of (P58 repressor) 1.17 0.94 NM_028410.1
Psmb8 Proteosome (prosome macropain) subunit beta type 8 (large multifunctional protease 7) 1.41 1.54 NM_010724
Ptpn2 Protein tyrosine phosphatase non-receptor type 2 18.90 6.05 AK076072
Socs1 Suppressor of cytokine signaling 1 1.63 1.16 NM_009896
Stat1 Signal transducer and activator of transcription 1 1.34 1.25 NM_009283.2
Stat2 Signal transducer and activator of transcription 2 3.27 3.24 NM_019963.1
Tap1 Transporter 1 ATP-binding cassette sub-family B (MDR/TAP) 1.59 2.85 NM_013683.1
Tyk2 Tyrosine kinase 2 1.22 0.97 NM_018793.1

Fold change, lung interferon gene expression 2 or 4 h after NTHi lysate treatment, compared to untreated mice. Accession, GenBank accession number. ND, no gene expression detected at the designated time point.