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. Author manuscript; available in PMC: 2009 Jan 5.
Published in final edited form as: J Pharmacol Exp Ther. 2007 Dec 20;324(3):1163–1171. doi: 10.1124/jpet.107.134593.

TABLE 1. Plasma DCA kinetics in humans.

Subjects received 12.5 mg/kg DCA. Data are mean ± S.D. of results obtained after the first DCA dose and after 6 months of daily exposure to 12.5 mg/kg every 12 h. Kinetic parameters were determined from a noncompartmental pharmacokinetic model using WinNonLin software, version 5.01.

Parameter First Dose
 Six Months
Children Adults Children Adults
No. subjects 5 4 5 4
Age (yr) 5.2 ± 1.8 24 ± 10 5.7 ± 1.8 24.5 ± 10
t1/2 (h) 2.5 ± 0.4 2.1 ± 1.5 6.4 ± 3.4 21 ± 5.8
Cmax (µg/ml) 23 ± 9.1 25 ± 6.6 35 ± 10 53 ± 18
AUC0–∞ (µg/ml · h) 83 ± 33 70 ± 18 340 ± 130 1500 ± 700
Clearance 150 ± 60 180 ± 46 37 ± 14 8.3 ± 4.6