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. Author manuscript; available in PMC: 2009 Jan 5.
Published in final edited form as: J Pharmacol Exp Ther. 2007 Dec 20;324(3):1163–1171. doi: 10.1124/jpet.107.134593.

TABLE 3. Plasma kinetics of DCA in rats.

Animals ranged in age from 5 to 7 weeks (young), to 7 months (adult), to 15 months (old), and they received 5 days of 50 mg/kg/day DCA, as described under Materials and Methods. Kinetic parameters were determined from a noncompartmental pharmacokinetic model using WinNonLin software, version 5.01. Data are mean ± S.D.

Parameter Rat Age Group
Young Adult Old
Cmax (µg/ml) 35 ± 5.0 24 ± 5 47 ± 15
Tmax (h) 1.8 ± 1.6 3.8 ± 2.3 2.8 ± 2.0
Mean residence time (h) 8.3 ± 1.2 10.5 ± 1.6 11.3 ± 1.4
Volume of distribution (ml) 0.44 ± 0.11 0.72 ± 0.09 0.40 ± 0.15
t1/2 (h) 4.5 ± 1.5 5.8 ± 1.3 7.0 ± 1.1
AUC0–∞ (µg/ml · h) 370 ± 47 290 ± 67 700 ± 220
CL (ml/h) 130 ± 17 170 ± 40 71 ± 22