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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Ann Neurol. 2008 Nov;64(5):555–565. doi: 10.1002/ana.21492

Figure 7.

Figure 7

Rescue of the mitochondrial membrane potential by experimental neuroprotective compounds. (A) Concentration response curve measuring mitochondrial membrane potential in 3 different parkin mutant fibroblasts lines treated with 2-oxo-4-thiazolidine carboxylic acid (OTCA). The horizontal line marks the control values for mitochondrial membrane potential. (B) The mitochondrial membrane potential is nearly normalized (95% of controls) with treatment of OTCA. Treatment with glutathione methyl ester (GME) results in less marked (65% of controls), but still significant increase, ** p < 0.01. (C) Complex I activity is not increased after treatment with OTCA. (D) In contrast, complex II activity is increased after treatment with -oxo-4-thiazolidine carboxylic acid (OTCA) in patient cells * p < 0.05. (E) Cellular ATP levels after treatment with OTCA are significantly increased in patient cells ** p < 0.01.