Scheme 4.
Synthesis of an ether analogue of β-naphthoyl-Pbtx. a) NaH, NaI, THF, 0 °C, 1 h; b) 2-(bromomethyl)naphthalene, DMF, 0 °C to RT, overnight, 65%.
Synthesis of an ether analogue of β-naphthoyl-Pbtx. a) NaH, NaI, THF, 0 °C, 1 h; b) 2-(bromomethyl)naphthalene, DMF, 0 °C to RT, overnight, 65%.