Table I.

Comparison of the skewed CDR3-size lengths of host-presensitized B6 CD8⁺ T cells from the GVHD-target organs of transplanted BALB.B versus CXB-2 recipient mice^a

	Spleen		Intestine		Liver
Vβ	BALB.B	CXB-2	BALB.B	CXB-2	BALB.B	CXB-2
1	—	192, 198	198, 201	192	—	192
2	—	167	—	152, 167	—	—
3	147, 150	153	147, 153	150	144	—
4	187	—	—	—	190	187, 193
5	—	—	185	—	—	—
6	—	155	—	—	149	149, 155
7	180	180, 186	180	180, 186	180, 186	186
8.1	139	148	136, 139	136	142	—
8.2	151	151	—	151	151	145
8.3	156, 162	—	153, 162	156	156	168
9	—	—	147	—	153	—
10	138	—	147	144, 147	132, 144	—
11	—	157	154	157	—	157
12	—	—	—	201	—	204
13	—	—	172	—	—	160
14	152, 164	152, 164	152, 158,* 161*	152, 164	152	149, 152, 164
15	183	—	183	183	177	183
16	145	—	145	154	145	154
18	222	222	207	207, 222	207	207
20	197, 200, 203	188, 200, 203	200, 203	194	197, 200	191, 203

^aLethally irradiated BALB.B and CXB-2 mice were injected with 2 × 10⁷ host-presensitized B6 donor T cells, respectively. GVHD-target tissue infiltrating lymphocytes were isolated and CDR3-size spectratype analysis was performed as described in the Materials and Methods section. CDR3-size length skewing was determined by comparison of the experimental spectratypes to those of normal B6 control for the respective Vβ family; the highlighted bands are common to both BALB.B and CXB-2 recipients; —, No skewing; ND, Not determined;

^*, Unique skewing. Results were averaged from three separate experiments.