Table 14.

Table of drugs to treat symptomatic DPN

Class	Examples	Typical doses*
Tricyclic drugs	Amitriptyline	10–75 mg at bedtime
	Nortriptyline	25–75 mg at bedtime
	Imipramine	25–75 mg at bedtime
Anticonvulsants	Gabapentin	300–1,200 mg t.i.d.
	Carbamazepine	200–400 mg t.i.d.
	Pregabalin†	100 mg t.i.d.
5-hydroxytryptamine and norepinephrine uptake inhibitor	Duloxetine†	60–120 mg daily
Substance P inhibitor	Capsaicin cream	0.025–0.075% applied t.i.d. or q.i.d.

^*Dose response may vary; initial doses should be low and titrated up.

^†Has FDA indication for treatment of painful diabetic neuropathy.