Figure 4. Cryptic chromosomal abnormalities can be detected by A-CGH in patients with abnormal as well as normal karyotypes.
A. By metaphase karyotype analysis approximately 50% of patients had detectable chromosomal abnormalities. In addition 2 patients were non-informative due to a lack of growth of the culture. By A-CGH the number of patients with chromosomal abnormalities increased to 32; the non-informative cases were resolved. B. The number of lesions detected by A-CGH for patients with low- and high-grade MDS, as well as CMML is shown. Longer lines marks the average number of lesions while the shorter lines mark one standard deviation.