Table 3.
Shared genomic regions of change as detected by A-CGH.
| Clone | Cytogenetic localization | Sample and change | Genes |
|---|---|---|---|
| RP11-421C4 | 1p36.3 | 17 G, 34G | MRPL20 |
| RP4-703E10 | 1p36.32 | 10 G, 26 G, 28 G | |
| RP1-62I8 | 1p36.33 | 17 G, 21 G | |
| RP11-433J22 | 1q21.1 | 19 L, 26 G | ACP6, GJA5 |
| RP11-79M15 | 1q23.3 | 13 G, 19 L | CD48, SLAMF7, LY9* |
| RP11-2l82G6 | 2p24.3 | 13 G, 19 L | |
| RP11-30M1 | 2q32.3 | 19 L, 38 L | |
| RP11-155G3 | 3p25.3 | 13 G, 19 L | |
| RP11-63O1 | 3p26.3 | 19 L, 38 L | CNTN4 |
| RP11-745L2 | 3q13.13 | 19 L, 36 L | |
| RP11-81H11 | 4p15.1 | 13 G, 19 L | |
| RP11-6F19 | 4q32.3 | 13 G, 19 L | TLL1 |
| AC008406.7 | 5q31.1 | 19 L, 29 L | CATSPER3, PITX1, |
| RP11-15J20 | 5q31.3 | 13 G, 19 L, 24 G | DIAPH1, HDAC3*, FCHSD1, CENTD3 |
| RP11-81F7 | 6p21.1 | 13 G, 19 L | |
| RP1-129L7 | 6q12 | 19 G, 23 | |
| RP11-91B17 | 6q21 | 13 G, 19 L | SEC63, OSTM1 |
| RP1-225E12 | 6q24.1 | 17 G, 28 G | HECA |
| RP11-89B15 | 7p21.1 | 22 L, 28 L | MEOX2 |
| RP11-88D24 | 7q21.11 | 15 L, 28 L | |
| RP11-46O13 | 7q21.13 | 15 L, 28 L | |
| RP11-79O7 | 7q21.3 | 15 L, 28 L | |
| AC005064.3 | 7q22.1 | 15 L, 28 L | PRES, RELN |
| RP11-80P24 | 7q22.1 | 15 L, 28 L | CUTL1* |
| RP11-72J24 | 7q22.3 | 15 L, 28 L | MLL5*, SRPK2 |
| RP11-77E2 | 7q31.1 | 15 L, 19 L | DLD, LAMB1, LAMB4 |
| RP11-110C11 | 7q31.2 | 15 L, 28 L | |
| RP11-51M22 | 7q31.2 | 15 L, 28 L | TES |
| RP11-112P4 | 7q31.32 | 15 L, 28 L | PTPRZ1 |
| RP11-140O21 | 7q31.31 | 15 L, 19 L | |
| RP11-17M8 | 8q24.23 | 26 L, 28 L, 32 L | |
| RP11-203L2 | 9q13 | 7 L, 19 L | PIP5K1B |
| RP11-108K14 | 10q26.3 | 5 G, 39 G | GTP, CYP2E1 |
| RP11-122K13 | 10q26.3 | 17 G, 19 L, 34 G | D26579, TUBGCP2*, ZNF511, DRD1IP, PRAP1, ECHS1, PAOX, GTP |
| RP11-288G11 | 10q26.3 | 17 G, 26 L | INPP5A |
| RP11-753M10 | 13q31.3 | 22 L, 23 L | |
| RP11-557O15 | 14q13.1 | 13 G, 19 L | NPAS3 |
| RP5-824J5 | 20q12 | 14 L, 33 L | |
| AL118506.27 | 20q13.3 | 17 G, 33 G, 34 G | TPD52L2, DNAJC5, UCKL1, SAMD10 |
| 122B5 | 22q11.21 | 17 G, 19 G | |
| RP3-355C18 | 22q13.33 | 17 G, 34 G | MLC1 |
The identities of clones that are altered in 2 or more samples are shown. Cytogenetic localization and genes within the clones were identified using the UCSC Human Genome Browser (http://www.genome.ucsc.edu/cgi-bin/hgGateway). Genes marked with * play a role in hematopoiesis, chromosomal stability and gene expression. G, gain; L, loss.