Table 1.

Summary of targeting strategies to inhibit IKK activity

Strategies	Potential targets	Therapeutic agents	References
Small molecule inhibitors	IKKα/β	PS-1145	Castro et al. (44), Hideshima et al. (45)
		BMS-345541	Burke et al. (46), McIntyre et al. (47)
		SPC-839	Palanki et al. (48)
		CHS828	Hiarnaa et al. (51), Olsen et al. (52)
	IKKβ	ML120B	Wen et al. (49)
		SC-514	Kishore et al. (50)
	TBK1	SU6668	Godl et al. (39)
RNA interference and small interfering RNAs	IKKα/β/ε and TBK1		Takaesu et al. (54)
Gene therapy	IKKβ	E1A	Shao et al. (55, 56)
Cell-permeable peptides	IKKα/β/γ complex	IKKβ [644–756] peptide	May et al. (61)