Glucagon, EPI, and NEPI responses to recurrent hypoglycemia with PBS or LIDO infusion into the THPVP. THPVP LIDO suppresses the NEPI response to a third bout of hypoglycemia (RH), relative to THPVP PBS-infused RH subjects. Data for LIDO-infused subjects are expressed as a % of the identical, time-matched responses for PBS-infused subjects (all mean PBS responses being set to ‘100%’), and are shown as mean±standard error of the mean. See Table 1 for group sizes. ‘*’ indicates p<0.05 vs. PBS response, at the timepoint indicated.