Table 1. Glucose and neuroendocrine data with SH and RH.

	0 min (baseline)	30 min	60 min	90 min	120 min
SH (single bout of hypoglycemia)
Plasma glucose (mg/dl)
PBS	106±2	52±5	37±3	33±2	31±2
LIDO	103±3	52±4	39±2	31±2	32±2
Glucagon (pg/ml)
PBS	124±26	224±21	262±46	248±42	307±32
LIDO	127±9	248±25	351±36	299±34	384±37
ACTH (pg/ml)
PBS	25±7	62±14	208±38	307±54	319±56
LIDO	17±4	78±19	250±49	274±50	288±53
CORT (μg/dl)
PBS	6.3±1	11.6±1.8	19.5±1.7	22.5±1.3	24.2±1.3
LIDO	6.1±1.1	12.7±1.6	20.2±1.9	23.4±1.9	22.9±1.6
EPI (ng/ml)
PBS	94±10	412±93	2010±455	2618±489	3308±467
LIDO	93±11	620±181	2233±687	3113±425	2460±228
NEPI (ng/ml)
PBS	242±17	332±45	670±99	756±65	918±126
LIDO	257±21	428±49	706±134	881±85	761±40
RH (third bout of hypoglycemia)
Plasma glucose (mg/dl)
PBS	110±1	50±2	39±2	35±2	35±3
LIDO	109±3	51±2	41±2	39±2	36±2
Glucagon (pg/ml)
PBS	164±22	291±22	244±25	291±37	289±39
LIDO	142±3	250±18	230±21	238±16	415±49
ACTH (pg/ml)
PBS	11±2	70±19	133±20	322±55	284±27
LIDO	20±6	55±12	87±23	230±53	302±44
CORT (μg/dl)
PBS	5.7±0.8	10.1±1.1	17.6±1.1	21.4±0.8	23.4±1.1
LIDO	8.3±0.9	11.9±1.1	15.2±1.5	19.8±1.2	21.4±0.9
EPI (ng/ml)
PBS	93±20	530±127	1412±272	2634±346	3341±531
LIDO	114±15	441±56	986±181	1942±282	2370±347
NEPI (ng/ml)
PBS	206±15	353±33	572±65	794±77	971±115
LIDO	258±24	314±28	449±40	664±66	769±76

Plasma glucose, glucagon, adrenocorticotropic hormone (ACTH), corticosterone (CORT), epinephrine (EPI), and norepinephrine (NE) measures taken at baseline (t.0 min) and at 30 min intervals throughout a 2-h bout of hypoglycemia. PBS (phosphate buffered saline) and LIDO (lidocaine) infusions were made into the THPVP. Values are represented as the mean±SEM.