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The SH2D4A adapter protein. A, Protein sequence alignment of human and murine SH2D4A. B, Protein sequence alignment of the SH2 domains of murine SH2D4A, TSAd, and ALX. C, Domain organization of murine SH2D4A, TSAd and ALX proteins. In A and B, residues that are identical or homologous between sequences are boxed. In A and C, the locations of SH2 domains, proline-rich regions (PRR) and conserved tyrosine residues in consensus phosphorylation motifs are indicated.
