Fig. 5.

The complete sequence of carbonic anhydrase XII. The 11 amino acid residues missing in the shorter isoform are shown in boldface and italics. The GXXXG and GXXXS motifs are underlined. The transmembrane region was predicted with three programs (TMHMM [http://www.cbs.dtu.dk/services/TMHMM-2.0/], TMpred [http://www.ch.embnet.org/software/TMPRED_form.html], TopPred [http://bioweb.pasteur.fr/seqanal/interfaces/toppred.html]), and the N-terminal helix prediction of these programs differed slightly: the area that showed differences is shown in light gray, and the common transmembrane sequence prediction by these programs is shown in dark gray.