Table 1.
Patient and disease characteristics (n = 355)
| n | % | |
|---|---|---|
| Gender | ||
| Male | 217 | 61.1 |
| Female | 138 | 38.9 |
| AJCC stage at melanoma diagnosis | ||
| I–II | 233 | 65.6 |
| III | 64 | 18.0 |
| IV | 58 | 16.3 |
| Race | ||
| Caucasian | 349 | 98.3 |
| Hispanic | 5 | 1.4 |
| African American | 1 | 0.3 |
| Brain metastasis at diagnosis of stage IV | ||
| No | 181 | 51.0 |
| Yes | 174 | 49.0 |
| Neurologic symptoms at diagnosis of brain metastasis | ||
| Asymptomatic | 116 | 32.7 |
| Focal | 107 | 30.1 |
| Nonfocal | 88 | 24.8 |
| Seizures | 39 | 11.0 |
| Unknown | 5 | 1.5 |
| Extracranial metastasis at diagnosis of brain metastasis | ||
| No | 57 | 16.1 |
| Yes | 296 | 83.4 |
| Unknown | 2 | 0.5 |
| Parenchymal metastasis | ||
| No | 7 | 2.0 |
| Yes | 346 | 97.5 |
| Unknown | 2 | 0.5 |
| Number of parenchymal brain metastases | ||
| 0 | 7 | 2.0 |
| 1 | 128 | 36.1 |
| 2–3 | 85 | 23.9 |
| ⩾4 | 130 | 36.6 |
| Unknown | 5 | 1.4 |
| Hemorrhagic brain metastasis | ||
| Yes | 123 | 34.6 |
| No | 219 | 61.7 |
| Unknown | 13 | 3.7 |
| Leptomeningeal metastasis | ||
| Yes | 40 | 11.3 |
| No | 315 | 88.7 |
| Hydrocephalus | ||
| Yes | 26 | 7.3 |
| No | 313 | 88.2 |
| Unknown | 16 | 4.5 |
| Lung metastasis | ||
| Yes | 201 | 56.6 |
| No | 154 | 43.4 |
| Visceral/bone metastasis | ||
| Yes | 135 | 38.0 |
| No | 220 | 62.0 |
| Lymph node/soft tissue metastasis | ||
| Yes | 190 | 53.5 |
| No | 165 | 46.5 |
Abbreviation: AJCC, American Joint Committee on Cancer.