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. Author manuscript; available in PMC: 2010 Jan 3.
Published in final edited form as: Behav Brain Res. 2008 Jul 31;196(1):30–36. doi: 10.1016/j.bbr.2008.07.028

Figure 1.

Figure 1

Counts of Fos-immunoreactive Nuclei Following Acute or Delayed Phase Emesis in the Least Shrew. Fos-IR nuclei in the dorsal vagal complex (DVC) were analyzed for each nuclear region in the DVC. Induction of Fos (and vomiting) was through treatment with 10 mg/kg CIS (i.p.). Means and standard errors of Fos-IR nuclei are graphed for each pre-treatment condition, each subnucleus of the DVC, and both phases of CIV. Significantly reduced numbers of Fos-immunopositive nuclei (* p < 0.05) were noted after THC injection when compared to either the vehicle or SR141716A+THC conditions. When regions of the DVC having the same treatment conditions were compared between acute and delayed phases, the AP and NTS had significantly fewer († p < 0.05) Fos+ nuclei in the delayed phase than in the acute phase of emesis when treated with vehicle or SR141716A+THC, but not when treated with THC alone (p > 0.1). Numbers of Fos+ nuclei in the DMNX during the delayed phase were not significantly different from the acute phase (p > 0.12). Abbreviations: AP – area postrema; DMNX – dorsal motor nucleus of the vagus nerve; NTS – nucleus of the solitary tract.