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. Author manuscript; available in PMC: 2009 Jan 5.
Published in final edited form as: Development. 2007 Jan 17;134(4):801–811. doi: 10.1242/dev.02773

Fig. 1.

Fig. 1

Loss of Notch2 causes hypoplastic kidneys that do not develop glomeruli, proximal tubules and S-shaped bodies. (A to D) The urinary system from postnatal day 1 and day 2 wild type (A, B) or mutant (C, D) animals. Notice the size difference of the urinary bladder (arrow in A and C). The mutant animals show spotty hemorrhage on the kidneys before they die on postnatal day 2 (D). (E to H) Histology of day 2 kidneys from wild type (E, F) and mutant (G, H) stained with H&E. Blue arrows flank the nephrogenic zone. Red arrow: glomerulus. Green arrow: proximal tubule. Yellow arrow: S-shaped body. Turquoise arrowhead: collecting duct. Green arrowhead: presumptive renal tubule in mutant. P: proximal tubule. D: distal tubule. The wild type genotype is Pax3-cretg/+; N2f/+; the mutant genotype is Pax3-cretg/+; fN2/fN2. Bar, 1mm (A to D), 0.1mm (E to H). Red arrows mark glomeruli, green-proximal tubule (marked also with P), turquoise- duct, yellow- S-shaped bodies, dark blue- nephrogenic zone. D indicates distal tubules.