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(A, B) At E9.0, Shh is expressed in the ventral forebrain and midbrain, ventral neural tube and notochord of the wild type embryo (A). In the Slb mutant (B), Shh expression is severely reduced in the ventral forebrain (arrows in A and B), but appears normal elsewhere. (C, D) At E9.0, Gli1 mRNA expression is abolished in the forebrain (arrows) and severely reduced in the midbrain of the mutant (D) as compared to a wild type littermate (C).
