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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2008 Jul 1;19(10):1467–1475. doi: 10.1016/j.jasms.2008.06.020

Figure 5.

Figure 5

Two-dimensional schematic representation of the template model of peptidoglycan biosynthesis for E. faecium. Chain extension occurs from right to left and is synchronized with cross-linking at lipid II. The few peptidoglycan stems terminating in D-Ala-D-Ala (red) occur in nascent and template peptidoglycan where they are cross-linked. We suspect that L,D-carboxypeptidase acts on stems in mature peptidoglycan that are not cross linked. We propose that other cell-wall editing enzymatic processes occur in mature peptidoglycan as well, creating muropeptides with O-acetylation (green), D-asparagine (blue), and cyclic imides (purple) as shown.