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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Clin Liver Dis. 2008 Nov;12(4):769–viii. doi: 10.1016/j.cld.2008.07.005

Fig. 2.

Fig. 2

In liver injury, ROS and RNS are generated in all liver cells. O2· − can react with NO· to generate ONOO− and other metabolites that may impact the HSC fibrogenic response in the early stages of cellular activation. ONOO− and its metabolites lower collagen I protein by increasing TNFα and inducing nitration of MMP1 with the subsequent cleavage of collagen I. These effects can be reverted by ONOO− chelating agents.