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. Author manuscript; available in PMC: 2009 Jan 5.
Published in final edited form as: Clin Cancer Res. 2006 Sep 15;12(18):5346–5355. doi: 10.1158/1078-0432.CCR-06-0968

Figure 2. Curcumin inhibits NT-mediated IL-8 mRNA and secretion.

Figure 2

A. HCT116 cells were pretreated with curcumin at the indicated concentrations for 25 min, and then treated with NT (100 nM) for 2 h. RNA was isolated and analyzed by RPA using the hCK-5 multi-probe. B. HCT116 cells were seeded in plates in McCoy’s 5A media with FBS. One days later, the media was changed to serum free for 24 h, pretreated with curcumin at the indicated concentrations for 30 min, and then treated with NT (100 nM) for 8 h. IL-8 secretion was measured in the conditioned media by ELISA. (Results are shown as mean ± SD and representative of three separate experiments; * = p < 0.05 vs control, † = p < 0.05 vs NT only).