Table 4.
Genes differentially expressed (1.5-fold) at ≥ 6 time points
| Symbol | Day 3 | Day 6 | Day 10 | Day 13 | Day 27 | Day 42 | Day 70 | Description |
| Up regulated | ||||||||
| Gene name | Other name/function | |||||||
| AGRN | 2.1 | 1.7 | 2.1 | 1.9 | 1.6 | 1.7 | 2.1 | agrin |
| APOBEC3A | 2.9 | 2.0 | 2.7 | 1.9 | 1.9 | 1.8 | 2.0 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A |
| CHMP5 | 2.8 | 1.9 | 2.6 | 2.0 | 1.9 | 1.8 | 1.9 | chromatin modifying protein 5 |
| DDX58 | 2.8 | 1.8 | 2.6 | 1.7 | 1.8 | 1.6 | 1.7 | RNA helicase RIG-I |
| EIF2AK2 | 2.6 | 1.9 | 2.6 | 2.2 | 2.0 | 2.0 | 2.4 | Eukaryotic translation initiation factor 2-alpha kinase 2 |
| FLJ11286 | 1.8 | 1.5 | 1.8 | 1.6 | 1.5 | 1.6 | 1.6 | C19orf66 |
| FLJ20035 | 3.8 | 3.0 | 3.6 | 2.7 | 2.5 | 2.6 | 2.7 | DDX60 |
| H1F0 | 3.1 | 1.6 | 2.1 | 1.8 | 1.9 | 2.1 | 2.5 | H1 histone family, member 0 |
| HERC5 | 4.5 | 2.1 | 4.1 | 2.5 | 2.6 | 2.5 | 2.7 | Ubiquitin ligase/mediates ISGylation of protein targets |
| HERC6 | 5.9 | 4.1 | 5.7 | 4.1 | 4.1 | 4.2 | 4.2 | Ubiquitin ligase |
| HIST1H1C | 2.6 | 1.6 | 2.4 | 1.7 | 2.6 | 2.4 | 3.2 | histone cluster 1, H1c |
| HIST1H2AE | 2.4 | 2.0 | 3.3 | 2.1 | 2.5 | 2.6 | 3.8 | histone cluster 1, H2ae |
| HIST1H2BC | 2.5 | 2.0 | 2.7 | 1.9 | 2.0 | 2.2 | 2.8 | histone cluster 1, H2bg///histone cluster 1, H2bc |
| HIST1H2BD | 2.1 | 1.7 | 2.3 | 1.6 | 1.7 | 1.6 | 2.2 | histone cluster 1, H2bd |
| HIST1H2BF | 2.4 | 1.9 | 2.5 | 1.8 | 1.9 | 1.5 | 2.2 | histone cluster 1, H2bf |
| HIST1H2BG | 4.3 | 2.8 | 3.6 | 3.5 | 3.3 | 2.4 | 3.4 | histone cluster 1, H2bg |
| HIST1H2BI | 2.4 | 1.9 | 2.5 | 1.9 | 2.0 | 1.5 | 2.2 | histone cluster 1, H2bi |
| HIST2H2AA3 | 3.1 | 1.8 | 2.8 | 1.8 | 2.1 | 2.1 | 2.8 | histone cluster 2, H2aa3///histone cluster 2, H2aa4 |
| IFI27 | 73.3 | 70.3 | 98.0 | 93.5 | 94.8 | 97.4 | 107.7 | interferon, alpha-inducible protein 27 (ISG12, P27) |
| IFI35 | 3.2 | 2.0 | 2.9 | 2.0 | 1.8 | 1.9 | 1.9 | interferon-induced protein 35 |
| IFI44 | 7.1 | 4.8 | 6.5 | 4.8 | 4.5 | 5.2 | 5.0 | Interferon-induced protein 44, p44 |
| IFI44L | 10.1 | 8.2 | 9.7 | 7.6 | 7.5 | 8.0 | 8.4 | interferon-induced protein 44-like |
| IFIH1 | 3.3 | 2.0 | 3.3 | 2.4 | 2.1 | 2.3 | 2.2 | interferon induced with helicase C domain 1 |
| IFIT1 | 12.2 | 4.1 | 9.9 | 6.0 | 4.8 | 5.6 | 4.8 | interferon-induced protein with tetratricopeptide repeats 1 |
| IFIT3 | 7.1 | 3.3 | 6.8 | 3.8 | 3.4 | 3.5 | 3.9 | interferon-induced protein with tetratricopeptide repeats 3 |
| IFIT5 | 2.7 | 1.9 | 2.7 | 2.4 | 2.0 | 2.2 | 1.8 | interferon-induced protein with tetratricopeptide repeats 5 |
| IFITM1 | 2.0 | 1.6 | 1.9 | 1.7 | 1.7 | 1.7 | 1.7 | interferon induced transmembrane protein 1 (9–27) |
| IFITM3 | 2.2 | 1.8 | 2.1 | 1.8 | 1.7 | 1.8 | 2.0 | interferon induced transmembrane protein 3 (1-8U) |
| IRF7 | 3.7 | 2.4 | 3.3 | 2.5 | 2.2 | 2.5 | 2.4 | interferon regulatory factor 7 |
| ISG15 | 6.8 | 3.8 | 6.6 | 4.0 | 3.9 | 4.4 | 4.2 | ISG15 ubiquitin-like modifier |
| ISG20 | 2.5 | 1.8 | 2.6 | 1.8 | 1.7 | 1.6 | 1.7 | interferon stimulated exonuclease gene 20kDa |
| LAMP3 | 6.0 | 3.1 | 6.7 | 3.3 | 3.8 | 3.9 | 4.4 | lysosomal-associated membrane protein 3 |
| LGALS3BP | 4.0 | 2.2 | 4.0 | 2.8 | 2.6 | 3.0 | 3.1 | lectin, galactoside-binding, soluble, 3 binding protein |
| LOC26010 | 4.3 | 2.5 | 4.2 | 3.0 | 3.0 | 3.1 | 3.3 | viral DNA polymerase-transactivated protein 6 |
| LOC391020 | 2.7 | 2.0 | 2.7 | 2.2 | 2.1 | 2.2 | 2.5 | interferon induced transmembrane protein pseudogene |
| LY6E | 4.1 | 2.7 | 4.0 | 3.1 | 2.8 | 3.0 | 3.4 | lymphocyte antigen 6 complex, locus E |
| MX1 | 5.0 | 3.5 | 4.9 | 3.8 | 3.7 | 3.9 | 4.1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
| MX2 | 3.1 | 2.1 | 2.9 | 2.2 | 2.2 | 2.3 | 2.4 | myxovirus (influenza virus) resistance 2 (mouse) |
| N4BP1 | 1.5 | 1.5 | 1.7 | 1.6 | 1.6 | 1.7 | 1.6 | Nedd4 binding protein 1 |
| OAS1 | 4.3 | 2.4 | 3.8 | 2.5 | 2.1 | 2.3 | 2.3 | 2',5'-oligoadenylate synthetase 1, 40/46kDa |
| OAS2 | 3.5 | 2.4 | 3.4 | 2.9 | 2.4 | 2.5 | 2.5 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| OAS3 | 4.5 | 2.6 | 3.8 | 2.7 | 2.3 | 2.5 | 2.8 | 2'-5'-oligoadenylate synthetase 3, 100kDa |
| OASL | 4.6 | 2.1 | 4.1 | 2.7 | 2.2 | 2.5 | 2.6 | 2'-5'-oligoadenylate synthetase-like |
| PARP12 | 2.4 | 1.8 | 2.3 | 1.8 | 1.8 | 1.9 | 1.9 | poly (ADP-ribose) polymerase family, member 12 |
| PHF11 | 1.8 | 1.6 | 1.8 | 1.6 | 1.7 | 1.7 | 1.7 | PHD finger protein 11 |
| PLSCR1 | 3.1 | 1.9 | 2.8 | 2.1 | 2.1 | 2.1 | 2.4 | phospholipid scramblase 1 |
| RNASE2 | 2.9 | 1.9 | 2.3 | 1.8 | 1.7 | 1.7 | 1.9 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) |
| RSAD2 | 12.8 | 5.3 | 11.6 | 6.8 | 6.4 | 6.4 | 6.6 | radical S-adenosyl methionine domain containing 2 |
| SAMD9 | 3.8 | 2.1 | 3.3 | 2.6 | 2.1 | 2.1 | 2.0 | sterile alpha motif domain containing 9 |
| SERPING1 | 4.9 | 1.9 | 4.1 | 2.3 | 1.9 | 2.0 | 2.1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) |
| SIGLEC1 | 27.1 | 16.5 | 23.1 | 17.0 | 13.7 | 18.2 | 20.9 | sialic acid binding Ig-like lectin 1, sialoadhesin |
| SP100 | 1.9 | 1.7 | 1.9 | 1.6 | 1.6 | 1.5 | 1.8 | SP100 nuclear antigen |
| SP110 | 1.9 | 1.5 | 1.9 | 1.5 | 1.5 | 1.5 | 1.6 | SP110 nuclear body protein |
| USP18 | 7.4 | 4.9 | 7.5 | 5.1 | 4.5 | 5.3 | 5.5 | ubiquitin specific peptidase 18 |
| XAF1 | 4.3 | 3.3 | 3.8 | 2.9 | 2.9 | 2.5 | 3.1 | XIAP associated factor-1 |
| ZBP1 | 3.0 | 2.2 | 3.0 | 2.2 | 2.1 | 2.2 | 2.2 | Z-DNA binding protein 1 |
| ZCCHC2 | 2.3 | 1.9 | 2.2 | 1.7 | 1.8 | 1.8 | 1.8 | zinc finger, CCHC domain containing 2 |
| cDNA CSODK002YF13 | 3.3 | 2.6 | 3.4 | 2.6 | 2.5 | 2.7 | 2.8 | Full-length cDNA clone CS0DK002YF13 of HeLa cells Cot 25-normalized of Homo sapiens (human) |
| cDNA FLJ11754 | 3.1 | 2.4 | 3.1 | 2.3 | 2.6 | 2.6 | 2.6 | CDNA FLJ11754 fis, clone HEMBA1005588 |
| Down regulated | ||||||||
| ALDH1A1 | -1.5 | -1.7 | -1.7 | -2.0 | -2.5 | -2.5 | -2.6 | aldehyde dehydrogenase 1 family, member A1 |
| CDKN1C | 1.9 | -2.1 | -1.1 | -1.7 | -1.7 | -1.7 | -1.7 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| EIF3EIP | -2.0 | -1.6 | -2.0 | -1.8 | -1.6 | -1.6 | -1.7 | eukaryotic translation initiation factor 3, subunit E interacting protein |
| EIF4B | -2.0 | -1.5 | -2.0 | -1.6 | -1.5 | -1.9 | -1.8 | eukaryotic translation initiation factor 4B |
| FCER1A | -1.5 | -1.7 | -2.1 | -2.2 | -2.4 | -3.0 | -2.8 | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| INSR | -1.5 | -1.6 | -1.6 | -1.9 | -2.0 | -2.0 | -1.6 | insulin receptor |
| LTA4H | -1.7 | -1.7 | -2.0 | -1.7 | -1.6 | -1.6 | -1.6 | leukotriene A4 hydrolase |
| PAPSS2 | -1.7 | -1.7 | -1.8 | -1.6 | -1.6 | -1.3 | -1.6 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| PID1 | -2.0 | -1.8 | -2.3 | -1.8 | -1.8 | -1.9 | -1.9 | phosphotyrosine interaction domain containing 1 |
| RTN1 | -2.2 | -1.9 | -2.3 | -2.0 | -2.0 | -2.0 | -2.3 | reticulon 1 |
Values in italics are not significant.